Maximizing ecological and evolutionary insight in bisulfite sequencing data sets
نویسندگان
چکیده
منابع مشابه
Strategies for analyzing bisulfite sequencing data.
DNA methylation is one of the main epigenetic modifications in the eukaryotic genome; it has been shown to play a role in cell-type specific regulation of gene expression, and therefore cell-type identity. Bisulfite sequencing is the gold-standard for measuring methylation over the genomes of interest. Here, we review several techniques used for the analysis of high-throughput bisulfite sequenc...
متن کاملimproved alignment of bisulfite sequencing data using cpg islands
dna methylation is an important biological process involving in human disease such as cancer insomia and diabetes. bisulfite sequencing (bs-seq) with next-generation technology is an accurate method for measuring dna methylation. bs-seq data analysis is a considerable way to recognize methylated cytosines and several tools have been developed to analysis bs-seq such as bs-seeker, b-solana, brat...
متن کاملQuantifying Molluscan Body Size in Evolutionary and Ecological Analyses: Maximizing the Return on Data-collection Efforts
How does the choice of size metric, specimen selection, and taxonomic level affect the results of macroevolutionary or ecological analyses? Four molluscan data sets are used to address this question as follows. First, the relationships among various size metrics are examined using a morphometric data set of Late Cretaceous–Oligocene veneroid bivalves. Second, the relationship between the size o...
متن کاملFast and sensitive mapping of bisulfite-treated sequencing data
MOTIVATION Cytosine DNA methylation is one of the major epigenetic modifications and influences gene expression, developmental processes, X-chromosome inactivation, and genomic imprinting. Aberrant methylation is furthermore known to be associated with several diseases including cancer. The gold standard to determine DNA methylation on genome-wide scales is 'bisulfite sequencing': DNA fragments...
متن کاملHBS-Tools for Hairpin Bisulfite Sequencing Data Processing and Analysis
The emerging genome-wide hairpin bisulfite sequencing (hairpin-BS-Seq) technique enables the determination of the methylation pattern for DNA double strands simultaneously. Compared with traditional bisulfite sequencing (BS-Seq) techniques, hairpin-BS-Seq can determine methylation fidelity and increase mapping efficiency. However, no computational tool has been designed for the analysis of hair...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nature Ecology & Evolution
سال: 2017
ISSN: 2397-334X
DOI: 10.1038/s41559-017-0229-0